Review of Systemic Immunosuppression for Autoimmune Uveitis
نویسندگان
چکیده
منابع مشابه
Review of Systemic Immunosuppression for Autoimmune Uveitis
The purpose of this review is to comprehensively examine the various therapeutic agents available to treat autoimmune eye disease, their indications, clinical safety and recent developments. The stepladder approach is reviewed, including corticosteroid administration of various forms, classic immunomodulators, and newer biologic response modifiers. The authors present that corticosteroid monoth...
متن کامل[Systemic autoimmune disease in patients with uveitis].
OBJECTIVE A descriptive study was conducted on patients with uveitis to determine the frequency of associated autoimmune systemic diseases. METHODS 64 patients with uveitis were studied. The patients were not known to have an underlying autoimmune systemic disease prior to the diagnosis of uveitis. All patients had the following immunological tests performed: serum immunoglobulins, complement...
متن کاملMechanisms Underlying Autoimmune Uveitis
Autoimmune uveitis is a group of HLA-associated inflammatory diseases of the eye, which can cause blindness. Patients exhibit cellular and humoral responses to immunologically privileged antigens resident in the eye. Animal models of uveitis, induced with these retinal antigens, serve an important role in studying disease mechanisms and therapies. On the basis of animal and clinical studies, T ...
متن کاملRat models of autoimmune uveitis.
Experimental autoimmune uveitis (EAU) in Lewis rats is a well-established model for human uveitis. During the last years we used this model to demonstrate extraocular induction of uveitis by antigenic mimicry of environmental antigens with retinal autoantigen and investigated the migration and intraocular reactivation of autoreactive green fluorescent protein (GFP)+ T cells. We could also elabo...
متن کاملUveitis and systemic disease.
A prospective study was conducted of 865 patients with uveitis to determine the frequency of associated systemic diseases and to assess the value of limited laboratory screening of these patients. All patients underwent a standard diagnostic protocol followed--when indicated--by special tests and procedures performed in order of likelihood ('tailored approach'). For 628 patients (73%) a specifi...
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ژورنال
عنوان ژورنال: Ophthalmology and Therapy
سال: 2014
ISSN: 2193-8245,2193-6528
DOI: 10.1007/s40123-014-0023-x